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Submitted: 16 May 2007 Modified: 07 November 2016
HERDIN Record #: PCHRDHE912197

Torsion dystonia in Panay, Philippines.

 Fuentes FD,
 Lee LV,
 Viterbo GH,
 Pascasio FM

There is an unusually high frequency of torsion dystonia in Panay. Of the 28 Filipino cases, 23 (82%) are from the island of Panay and 19 of the 23 (82%) are from the province of Capiz. The 28 cases belong to 25 families. Six sets of brothers are noted. All are males Pedigree analysis reveals six families with several members affected. Two families show features suggesting possible sex-linked recessive transmission, a mode of inheritance previously undescribed in the literature The clinical features of the cases seen in this series differ from previously described cases in the literature in several aspects : (a) sex preponderance - all males; (b) age at onset - older age onset, mean 31; (c) hereditary - possible sex-linked recessive transmission; (d) spasmodic eye blinking as first symptom in four patients.(Auth. Sum.)

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Adv Neurol
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1. Validation of a PCR-based test for the genetic diagnosis of Filipino patients with x-linked dystonia Parkinsonism (Xdp).
2. Suicidality among patients with sex-linked dystonia-parkinsonism (XDP).