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Submitted: 14 April 2009 Modified: 13 February 2014
HERDIN Record #: PCHRD041309110413

Lack of efficacy of high dose intravenous immunoglobulin treatment of severe thrombocytopenia in patients with secondary dengue virus infection.

Efren M. Dimaano,
Kazunori Oishi,
Edna A. Miranda,
Atsushi Kumaori,
Mariko Saito,
Myrna D. Valerio,
Shingo Inove,
Ronald Matias,
Cynthia A. Mapua,
Maria T. Alonzo,
Shoko Honda,
Filipinas F. Natividad

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Because most cases of secondary dengue virus infection are associated with an increased level of platelet-associated IgG, a high dose of intravenous immunoglobulin (IVIG) may have an effect on the development of severe thrombocytopenia in this disease. A randomized, controlled study was conducted with two treatment groups consisting of a treatment (IVIG) group (n = 15) and a non-treatment (non-IVIG) group (n = 16) to determine whether a high dose of IVIG is effective in hastening the recovery from thrombocytopenia in patients with secondary dengue virus infection. No significant difference was found in the baseline demographic data between the two groups. No adverse effect of IVIG was observed, but no effect in hastening the recovery of platelet counts was found in patients with secondary dengue infections. The lack of efficacy of IVIG suggests that platelet clearance by macrophages through Fc receptors is not a primary mechanism in this disease.

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
St. Luke's Journal of Medicine
Frequency
Semi-Annual
Publication Date
January-June 2010
Volume
6
Issue
1
Page(s)
59-62
LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library PCHRD041309110413 Abstract Print Format (Request Document)
Philippine Council for Health Research and Development Library box no. 35 Abstract pdf (Download)
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