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Submitted: 16 August 2011 Modified: 16 August 2011
HERDIN Record #: PCHRD08161104081274

The incidence of positive bone marrow AFB stains and culture for mycobacterium tuberculosis among patients presenting hematologic disorder.

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A total of 94 subjects with abnormal hematologic condition (1 month - 89 years) were used in this study. This project attempts to identify the presence of mycobacteria in the bone marrow and to determine the relationship between hematologic presentation and mycobacterial infection. It also attempts to determine other clinical features among patients with mycobacteriosis. The bone marrow was aspirated and 0.5 ml of the aspirate were placed in two Lowenstein-Jensen tubes for mycobacterial identification. The remaining specimens were stained for hematologic and mycobacterial studies. Chest X-ray were performed and a thermometer was used for evaluating fever in all patients.Results showed that ten(10.6

) of the 94 subjects have a positive colony growth of mycobacteria in the bone marrow aspirate. A statistically significant difference in the presence of fever and chest X-ray of hematologic patients revealed a correlation with mycobacteriosis. The physical examinations showing bleeding tendency, splenomegaly and hepatomegaly did not reach a significant difference for association with mycobacteriosis.It is proposed to have a diagnostic criteria for relating mycobacterial infection in the bone marrow.

Publication Type
Research Project
Date
May 31, 1989-February 28, 1990

Objectives

The study aims to: (1) determine the incidence of the presence of Mycobacterium tuberculosis (MTB) using Lowenstein Jensen culture media and AFB stains of the aspirate and biopsy specimens of the bone marrow in patients with hematologic abnormalities whose diagnosis cannot otherwise be made without doing bone marrow studies; (2) determine the sensitivity of the use of AFB staining against the use of Lowenstein Jensen culture in detecting MTB in the bone marrow; (3) determine which hematologic presentations are most commonly associated with MTB of the bone marrow; (4) determine whether bone marrow TB culture should be made a part of the routine investigative work-up of patients with hematologic abnormalities.


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